Episodes

  • I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496

    I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496
    Jul 5 2026

    Try Danger Creatine: https://dangercoffee.com/products/danger-creatine

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/

    Try Suppgrade Labs: https://shopsuppgradelabs.com/


    I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.


    The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.


    Thank you to our sponsors!

    • ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
    • iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Timestamps:

    0:00 – The Longevity Switch

    0:47 – Why Mitochondria Matter

    2:28 – What Mitophagy Is

    2:46 – How Mitophagy Works

    4:18 – What Shuts It Off

    8:54 – The Damage Compounds

    9:22 – How to Turn It Back On

    10:31 – Signal 1: Fasting

    11:48 – Signal 2: Exercise (REHIT)

    12:30 – Signal 3: Cold Exposure

    13:22 – Signal 4: NAD+

    14:29 – Signal 5: Urolithin A and Spermidine


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    17 mins
  • Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495

    Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495
    Jul 3 2026
    GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption. Source: https://www.nature.com/articles/s43856-026-01566-x ~~ GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy. Sources: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498 https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds ~~ Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk. Source: https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn ~~ Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost. Sources: https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/ https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/ ~~ Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations. Source: https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/ ~~ New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, ...
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    11 mins
  • 90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494

    90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494
    Jul 2 2026
    Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that challenges everything you think you know about fiber, cholesterol, and metabolic health. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Ben Azadi, founder of Keto Kamp and bestselling author of Metabolic Freedom. After overcoming obesity and severe health challenges, Ben has spent years educating millions of people on metabolic health, fasting, ketosis, and biohacking strategies through his podcast, books, and YouTube channel with over a million subscribers. He is known for turning complex science into practical tools anyone can use to burn fat, boost human performance, and support long-term longevity. Ben walks through what happened when he ate nothing but meat, eggs, and dairy for 90 straight days, tracking everything from his microbiome diversity to his LDL particle size. His cholesterol numbers spiked, but the full lipid panel tells a very different story than most doctors would assume. They get into why ketosis works better when you cycle in and out of it, how sodium and electrolytes play a bigger role in insulin resistance than most people realize, and why eating 17 to 23 times a day might be quietly wrecking your metabolism. The conversation also covers the real science behind creatine absorption, why Dave adds his to hot coffee for better brain uptake, the truth about cooking oils and smoke points, and why cold plunging is one of the most misunderstood biohacks in the wellness space. Dave and Ben dig into mitochondria, fasting protocols, sleep optimization, and the supplements that actually move the needle for energy, fat loss, and anti-aging. This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, and building a body that performs at a higher level for longer. You'll Learn: What 90 days of zero fiber actually did to his gut bacteria and microbiome diversity Why his cholesterol went up but his cardiovascular risk markers stayed low The real reason cyclical ketosis works better than staying in ketosis full time How sodium and electrolyte intake affects insulin resistance and metabolism Why eating too frequently keeps your body stuck in glucose and insulin spikes The creatine hack that increases brain absorption using hot coffee Why cold plunging is overrated for most people who skip the hormesis basics Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Ben Azadi, Keto Kamp, carnivore diet, 90-day carnivore experiment, gut microbiome, gut bacteria diversity, fiber-free diet, LDL particle size, cyclical ketosis, fasting, autophagy, electrolytes, sodium intake, insulin resistance, fasting insulin, creatine, blood-brain barrier, melatonin, mitochondria, hormesis, cold plunge, dopamine receptors, olive oil polyphenols, smoke point, beef tallow, seed oils, HRV, sleep optimization, KetoFlex, Metabolic Freedom Resources: • See All Of Ben Azadi's Content At: https://benazadi.com/ • Check Out Ben’s YouTube Channel: https://www.youtube.com/@KetoKamp • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses...
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    1 hr and 2 mins
  • Oxytocin: How To Naturally Induce Your MIRACLE Hormone | Anna Cabeca : 1493

    Oxytocin: How To Naturally Induce Your MIRACLE Hormone | Anna Cabeca : 1493
    Jun 30 2026
    Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal optimization, and why fixing your hormones can make your 70s the best decade of your marriage. Dr. Anna Cabeca is a triple board-certified OBGYN and fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine, with additional board certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She is the bestselling author of The Hormone Fix, Keto-Green 16, and MenuPause, and has spent decades researching the clinical intersection of oxytocin, cortisol, estrogen, and progesterone on women's hormonal health, metabolism, and longevity. Her work on keto-green nutrition, vaginal and bladder microbiome health, and bioidentical hormone replacement has made her one of the most credentialed and clinically experienced voices in women's functional medicine practicing today. Dave and Dr. Anna break down the real pharmacology of oxytocin, including its role in muscle regeneration, cortisol suppression, mitochondrial signaling, and vagal tone optimization. They expose the toxic ingredients hiding in mainstream lubricants and vaginal hormone creams, including aspartame, parabens, and petroleum derivatives, and explain why the vaginal microbiome is a frontline organ for women's metabolism and anti-aging. They get into the neuroscience of orgasm, pineal gland activation, endogenous DMT release, and the neurochemical cascade behind peak altered states. Dr. Anna also breaks down the Women's Health Initiative disaster, the FDA's recent reversal on bioidentical hormone replacement, and why FSH is a critical and widely overlooked longevity biomarker. High post-menopausal FSH drives neuroinflammation, accelerates bone loss, and degrades brain optimization outcomes, and most physicians are not testing for it. This is essential listening for anyone serious about biohacking, longevity, anti-aging, functional medicine, human performance, brain optimization, and taking full ownership of their biology. You'll Learn: Why oxytocin functions as a regenerative hormone that rebuilds muscle, suppresses cortisol, and supports mitochondria signaling What toxic chemicals are hiding in standard lubricants and vaginal hormone creams and what to use instead How orgasm activates the pineal gland and triggers endogenous DMT release and altered neurological states Why female intuition may be directly linked to mitochondrial density concentrated in the ovaries How elevated FSH drives neuroinflammation, bone loss, and accelerated brain aging in post-menopausal women Why the FDA reversed 30 years of flawed guidance on bioidentical hormone replacement therapy How four days of sensory deprivation supercharges melatonin, oxytocin, and endogenous DMT production Why oxytocin combined with ketamine is being used clinically to break trauma patterns and rewire neural pathways How polyphenols, CoQ10, carnitine, and vagal tone training protect cardiovascular health and support longevity Why polypharma accelerates decline and what functional medicine does differently Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Gatlan | Book your free consultation at www.gatlan.com/DAVE - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Anna Cabeca, The Girlfriend Doctor, oxytocin, bioidentical hormone replacement, FSH, follicle-stimulating hormone, vaginal microbiome, Velve lubricant, Julva, Mighty Maca, cortisol suppression, pineal gland, DMT, neuroinflammation, broken heart syndrome, NT-proBNP, vagal tone, dark retreat, orgasmic meditation, Women's Health Initiative, perimenopause, postmenopause, yoni massage, oxytocin nasal spray, ...
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    55 mins
  • BONUS: The Anti-Aging Molecule Backed by Nobel Prize Research : 1492

    BONUS: The Anti-Aging Molecule Backed by Nobel Prize Research : 1492
    Jun 28 2026

    You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it’s NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider.


    Thank you to our sponsors!

    • Gatlan | Book your free consultation at www.gatlan.com/DAVE
    • Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    • iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Timestamps:

    0:00 – The Longevity Switch

    0:47 – Why Mitochondria Matter

    2:28 – What Mitophagy Is

    2:46 – How Mitophagy Works

    4:18 – What Shuts It Off

    8:54 – The Damage Compounds

    9:22 – How to Turn It Back On

    10:31 – Signal 1: Fasting

    11:48 – Signal 2: Exercise (REHIT)

    12:30 – Signal 3: Cold Exposure

    13:22 – Signal 4: NAD+

    14:29 – Signal 5: Urolithin A and Spermidine


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    12 mins
  • Fish Oil Doesn’t Work? Anti-Aging Butterflies, the Ancient Brain Focus Switch, and the Best Brain Diet : 1491

    Fish Oil Doesn’t Work? Anti-Aging Butterflies, the Ancient Brain Focus Switch, and the Best Brain Diet : 1491
    Jun 26 2026
    Fish Oil Supplements And Alzheimer’s-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer’s-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer’s risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn’t always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer’s prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated ...
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    14 mins
  • The 'Secret Sauce' To A 10/10 Morning Routine : 1490

    The 'Secret Sauce' To A 10/10 Morning Routine : 1490
    Jun 25 2026
    Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash -Get 15% off your next order at: https://getmte.com/dave Host Dave Asprey sits down with Jeff Boyd, founder and chairman of MTE (More Than Energy), the caffeine-free energy drink built around adaptogens, nootropics, and prebiotics that delivers what Boyd calls "energy that loves you back." Before launching MTE, Jeff spent 15 years as President and co-owner of Luggage Free, scaling the company to operations in over 100 countries before selling it in 2019. He brings the operational discipline of a veteran entrepreneur and the personal conviction of someone who built the energy product he actually wanted to exist. Dave and Jeff get into the full science and strategy behind MTE's ingredient stack, including paraxanthine, ashwagandha, eleuthero, maca, GABA, theanine, and saffron, and why each one was chosen for its role in stress response, brain optimization, and sleep optimization. They also dig into the formulation challenges of building a clean-label supplement over a stimulant base, the real difference between caffeine and its downstream metabolite paraxanthine, and why this blend functions more like a foundational biohacking protocol than a beverage. You'll Learn: Why conventional energy drinks wreck your cortisol curve and what to do instead How paraxanthine delivers the benefits of caffeine without the jitters or sleep disruption The adaptogen trio (ashwagandha, eleuthero, and maca) and how they work together for stress response and human performance Why saffron is one of the most underrated nootropics for mood and brain optimization How gut health and the microbiome connect directly to your energy, metabolism, and longevity The mitochondria connection between willpower, physical performance, and entrepreneurial output How AI is reshaping small teams and what founders need to do right now to stay competitive Why the cleanest path to anti-aging and longevity starts with how you manage your energy across the day Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Gatlan | Book your free consultation at www.gatlan.com/DAVE - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jeff Boyd, MTE, More Than Energy, caffeine-free energy, paraxanthine, adaptogens, ashwagandha, eleuthero, maca, nootropics, saffron, GABA, theanine, prebiotics, gut health, stress response, cortisol management, sleep optimization, huckleberry acai, clean label formulation, stevia Reb A, energy drink alternative, paraxanthine vs caffeine, afternoon energy, Luggage Free, cycling endurance, long jump training, ADHD entrepreneurship, AI small teams, willpower mitochondria Resources: • Get 15% off your next order at: https://getmte.com/dave • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:42 – What Is MTE? 03:50 – Ingredients Deep Dive 09:49 – Flavors & Formulation 12:31 – Dave's Caffeine Origin 18:35 – Athletic Identity 22:38 – ADHD & Entrepreneurship 26:43 – AI & Future of Work 30:47 – Willpower & Mitochondria 35:34 – MTE Wrap-Up See Privacy Policy...
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    38 mins
  • The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489

    The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489
    Jun 23 2026
    Longevity, Trauma Recovery, Circadian Health, Ramadan Fasting & Biohacking Your nervous system may be aging you faster than your diet. Learn how childhood programming, stress, sleep, fasting, resilience, and environment shape longevity, healthspan, metabolism, and human performance, and discover why some of the most powerful upgrades for your biology have nothing to do with supplements, nootropics, or the latest biohacking trends. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Learn more about Dr. Abirached’s work at: https://limitlesshuman.ae/ Host Dave Asprey sits down with Dr. Elie Abirached, a Dubai-based longevity and biohacking strategist, Harvard alumnus, founder of Limitless Human, and CEO of Restore Fitness. After being smuggled out of Lebanon during the civil war as a teenager, he built a career helping high performers improve healthspan, resilience, recovery, metabolism, and longevity. Today he is one of the Middle East’s leading voices in biohacking, healthy aging, human performance, sleep optimization, and lifestyle-driven longevity. Together, they explore why Dubai has become a global hub for biohacking and longevity, how extreme heat, light exposure, fasting, and modern lifestyle habits affect human biology, and why nervous system health may be one of the most overlooked drivers of long-term performance and anti-aging. They also dive into trauma, neuroplasticity, emotional resilience, metabolism, brain optimization, sleep quality, and the hidden programming that shapes your reactions, relationships, and health outcomes. You’ll discover what the Middle East gets right about health and longevity, why resilience may be one of the most important predictors of healthy aging, and how your environment influences everything from recovery and mitochondria to sleep, energy, and mental performance. This episode offers practical insights for anyone interested in biohacking, human performance, longevity, fasting, sleep optimization, metabolism, brain optimization, emotional resilience, and building a stronger, more adaptable nervous system. You’ll Learn: • How childhood experiences and unconscious programming influence longevity, healthspan, and human performance • Why nervous system regulation may be one of the most powerful anti-aging tools available • What Dubai’s biohacking community gets right about health, recovery, and longevity • How fasting, including Ramadan-style fasting, affects metabolism, energy, and performance • The connection between neuroplasticity, emotional resilience, and brain optimization • How sleep optimization impacts mitochondria, recovery, aging, and cognitive function • Why environmental factors like heat, light exposure, air quality, and circadian rhythm matter more than most people realize • How to improve healthspan without relying solely on supplements, nootropics, ketosis, or the latest biohacking trends • Why stronger biology creates better decision-making, relationships, and long-term success • Practical strategies for building resilience in a world filled with stress, distraction, AI, and information overload Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. - Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. Use code DAVE30 for 30% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Elie Abirached, Dubai biohacking, UAE longevity, Middle East biohacking, Lebanon civil war survivor, resilience training, childhood trauma, nervous system regulation, emotional resilience, neuroplasticity, longevity medicine, healthy aging, human performance, sleep optimization, circadian rhythm, Ramadan fasting, intermittent fasting, metabolism optimization, stress adaptation, biological aging, mitochondria health, environmental health, heat adaptation, Dubai longevity, Limitless Human, Restore Fitness, healthspan, ...
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    25 mins