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The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

By: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Hygiene & Healthy Living Personal Development Personal Success Science
Episodes
  • I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496

    I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496
    Jul 5 2026

    Try Danger Creatine: https://dangercoffee.com/products/danger-creatine

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/

    Try Suppgrade Labs: https://shopsuppgradelabs.com/


    I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.


    The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.


    Thank you to our sponsors!

    • ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
    • iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Timestamps:

    0:00 – The Longevity Switch

    0:47 – Why Mitochondria Matter

    2:28 – What Mitophagy Is

    2:46 – How Mitophagy Works

    4:18 – What Shuts It Off

    8:54 – The Damage Compounds

    9:22 – How to Turn It Back On

    10:31 – Signal 1: Fasting

    11:48 – Signal 2: Exercise (REHIT)

    12:30 – Signal 3: Cold Exposure

    13:22 – Signal 4: NAD+

    14:29 – Signal 5: Urolithin A and Spermidine


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    17 mins
  • Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495

    Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495
    Jul 3 2026
    GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption. Source: https://www.nature.com/articles/s43856-026-01566-x ~~ GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy. Sources: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498 https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds ~~ Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk. Source: https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn ~~ Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost. Sources: https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/ https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/ ~~ Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations. Source: https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/ ~~ New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, ...
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    11 mins
  • 90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494

    90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494
    Jul 2 2026
    Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that challenges everything you think you know about fiber, cholesterol, and metabolic health. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Ben Azadi, founder of Keto Kamp and bestselling author of Metabolic Freedom. After overcoming obesity and severe health challenges, Ben has spent years educating millions of people on metabolic health, fasting, ketosis, and biohacking strategies through his podcast, books, and YouTube channel with over a million subscribers. He is known for turning complex science into practical tools anyone can use to burn fat, boost human performance, and support long-term longevity. Ben walks through what happened when he ate nothing but meat, eggs, and dairy for 90 straight days, tracking everything from his microbiome diversity to his LDL particle size. His cholesterol numbers spiked, but the full lipid panel tells a very different story than most doctors would assume. They get into why ketosis works better when you cycle in and out of it, how sodium and electrolytes play a bigger role in insulin resistance than most people realize, and why eating 17 to 23 times a day might be quietly wrecking your metabolism. The conversation also covers the real science behind creatine absorption, why Dave adds his to hot coffee for better brain uptake, the truth about cooking oils and smoke points, and why cold plunging is one of the most misunderstood biohacks in the wellness space. Dave and Ben dig into mitochondria, fasting protocols, sleep optimization, and the supplements that actually move the needle for energy, fat loss, and anti-aging. This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, and building a body that performs at a higher level for longer. You'll Learn: What 90 days of zero fiber actually did to his gut bacteria and microbiome diversity Why his cholesterol went up but his cardiovascular risk markers stayed low The real reason cyclical ketosis works better than staying in ketosis full time How sodium and electrolyte intake affects insulin resistance and metabolism Why eating too frequently keeps your body stuck in glucose and insulin spikes The creatine hack that increases brain absorption using hot coffee Why cold plunging is overrated for most people who skip the hormesis basics Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Ben Azadi, Keto Kamp, carnivore diet, 90-day carnivore experiment, gut microbiome, gut bacteria diversity, fiber-free diet, LDL particle size, cyclical ketosis, fasting, autophagy, electrolytes, sodium intake, insulin resistance, fasting insulin, creatine, blood-brain barrier, melatonin, mitochondria, hormesis, cold plunge, dopamine receptors, olive oil polyphenols, smoke point, beef tallow, seed oils, HRV, sleep optimization, KetoFlex, Metabolic Freedom Resources: • See All Of Ben Azadi's Content At: https://benazadi.com/ • Check Out Ben’s YouTube Channel: https://www.youtube.com/@KetoKamp • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses...
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    1 hr and 2 mins
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