What if the goal isn't simply to live longer—but to live better, for longer?

In this special kickoff episode of The Vitals Healthspan Miniseries, guest host Shruti Naik sits down with Mount Sinai experts Fiorina Kyritsi, MD, Miriam Merad, MD, PhD, and Zahi Fayad, PhD to explore the science of aging—and why the future of medicine may be less about extending lifespan and more about expanding health span.

The panel breaks down:

• what aging actually is
• why scientists still don't fully understand "healthy aging"
• how emerging research is helping identify the biomarkers that may one day predict—and potentially improve—our aging trajectories.

The panel also separates evidence from hype, tackling supplements, social-media longevity trends, personalized medicine, and the promise of large-scale research initiatives like the XPRIZE Healthspan competition.

🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt

How did ketamine evolve from an anesthetic to one of the most important mental health treatment breakthroughs in decades?

In this episode of The Vitals, guest host Dennis Charney, MD sits down with specialists James Murrough , MD, PhD, and Adriana Feder, MD, to explore the science behind ketamine treatment for depression and PTSD—and why it may offer hope for patients who have not responded to traditional therapies.

The conversation traces the origins of ketamine research to the pioneering clinical work conducted at Mount Sinai. The doctors explain how ketamine differs from standard antidepressants, why it can work within hours instead of weeks, and how it is helping patients with treatment-resistant depression and suicidal thinking.

The panel also discusses:

• How ketamine became the FDA-approved treatment Spravato
• Why researchers believe ketamine increases neuroplasticity in the brain
• The growing evidence for ketamine in treating PTSD
• How psychotherapy may enhance ketamine’s long-term effects
• Why patients should not lose hope, even after years of severe symptoms

To learn more about Mount Sinai’s Depression and Anxiety Center or to book an appointment with a Mount Sinai expert, visit the Mount Sinai Health System’s website: https://icahn.mssm.edu/research/depression-anxiety-center

🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt

Colorectal cancer is no longer just a disease of older adults—and the data is raising alarm bells.

On this episode of The Vitals, host Leslie Schlachter sits down with the Mount Sinai Health System’s leading experts

To unpack why rates are rising, especially among younger populations, and what you need to know right now.

Joining the conversation are gastroenterologists Dr. David Greenwald and Dr. Pascale White, along with medical oncologist Dr. Deirdre Cohen. Together, they explore the latest research, evolving screening guidelines, and breakthrough treatments that are changing outcomes for patients.

From early warning signts to cutting-edge therapies, this episode delivers practical, evidence-based insights that could change lives:

• The likely reasons why colorectal cancer is increasing in adults under 50;
• Common symptoms you should never ignore;
• Screening options—from stool tests to colonoscopy—and when to start;
• The role of lifestyle, diet, and the microbiome;
• Advances in treatment, including immunotherapy and personalized medicine;
• How early detection dramatically improves survival.

Colorectal cancer is one of the most preventable—and treatable—cancers when caught early. Whether you’re approaching screening age or simply want to stay informed, this conversation is essential listening.

📞For more information on Mount Sinai’s colorectal cancer treatments or to schedule an appointment with a Mount Sinai physician, click here: https://www.mountsinai.org/care/gastroenterology/services/endoscopy-colonoscopy/colonoscopy/colorectal-screening

🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt