Episodes

  • Nobody Tells You What GLP-1s Do to Your Sex Drive | GLS #213

    Nobody Tells You What GLP-1s Do to Your Sex Drive | GLS #213
    Jun 25 2026
    The receptor that switches off your appetite on a GLP-1 drug is the same one wired into your reward circuitry, your hormones, and your blood vessels, which means when you turn down hunger, something else may be getting turned down too, and for most people taking these drugs, nobody ever checked.In this solo episode, Dr. Gabrielle Lyon discusses:Why the same drug class can improve sexual function in men with obesity while potentially dampening it in lean or postmenopausal women — and why the deciding factor isn't the drug, it's the bodyHow rapid weight loss raises SHBG, the protein that soaks up free testosterone, so a "normal" total testosterone result can hide a real deficit your bloodwork won't flagWhy women make up 60–70% of GLP-1 prescriptions yet the entire evidence base for female sexual function is two case reports, with zero validated questionnaires in any pivotal trialThe three-tier action plan for anyone on or about to start a GLP-1 — baseline your sexual function first, get free testosterone tested, and protect muscle with protein and resistance trainingWhether you're on a GLP-1 drug or considering one, you'll walk away knowing exactly what to measure before you start and what to watch for after — so a change in your sexual health gets caught as the vital sign it is, instead of being quietly dismissed.Thank you to our sponsors:Cozy Earth - Go to https://bit.ly/44qcXtu for up to 20% off! Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/3QEpYMX or find yours in store at https://bit.ly/3SGAEv3 .Kettle & Fire - Head to https://bit.ly/4oJokGu and use code DRLYON for 25% off sitewide. That is K-E-T-T-L-E and Fire dot com slash DRLYON, code DRLYON for 25% off. Also available at select Sprouts, Whole Foods, and Kroger locations nationwide.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction01:30 - The 35-year-old patient case04:00 - The question: harm or help?05:00 - The case against: the 4.5x ED study06:30 - FAERS database and 182 reports08:00 - Reward circuits, blood flow, and SHBG11:00 - Women are 70%, the data is two case reports12:30 - The case for: detection bias explained15:00 - Validated studies show testosterone rising17:00 - GLP-1 vs testosterone therapy and fertility19:00 - Same receptor, different body22:00 - Cross-examination: holes in both sides26:00 - Why the drugs may not all be the same30:00 - Confidence levels: what Lyon actually believes33:00 - Tier 1: baseline, hormones, protein, training35:00 - Tier 2 and 3: dose, molecule switch, adjuncts36:30 - Your sexuality is a vital sign If you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    38 mins
  • Why Strength Beats Cardio After 50: Muscle, Longevity & Bone Density - Lisa Smith-Batchen

    Why Strength Beats Cardio After 50: Muscle, Longevity & Bone Density - Lisa Smith-Batchen
    Jun 23 2026
    You might think more cardio is the key to aging well but Lisa Smith-Batchen, who has run 135 miles through Death Valley ten times, says it's strength that actually carries you through the decades.In this episode, Dr. Gabrielle Lyon sits down with Lisa Smith-Batchen, one of the most decorated ultra-endurance athletes in American history and a 10-time Badwater 135 finisher, to discuss:Why being strong matters more than being fast and why "it's not the running that helps me run, it's being strong"The first movement everyone should train at any age: sit to stand, followed by squats, wall sits, lunges, and pushupsWhy cutting protein after 60 backfires, and why Lisa fuels on roughly 80% protein calories during racesHow to start lifting late, her 85-year-old client went from 5-pound weights to 230-pound farmer carriesThe fall that ended her father's life, and why "pick your feet up" became her mission for aging athletesYou'll walk away with a clear, muscle-first blueprint for staying strong, mobile, and independent for life — and the motivation to start today instead of waiting for another Monday.Thank you to our sponsors:Cozy Earth - Go to https://bit.ly/44qcXtu for up to 20% off!Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/3QEpYMX or find yours in store at https://bit.ly/3SGAEv3 .Kettle & Fire - Head to https://bit.ly/4oJokGu and use code DRLYON for 25% off sitewide. That is K-E-T-T-L-E and Fire dot com slash DRLYON, code DRLYON for 25% off. Also available at select Sprouts, Whole Foods, and Kroger locations nationwide.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Lisa Smith-Batchen at:Website: https://dreamchaserevents.com/Instagram: https://www.instagram.com/coachlisasmithbatchenFacebook: https://www.facebook.com/lisa.smithbatchenConnect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction02:10 - From marathon to the Badwater 13505:31 - The first race and learning the hard way06:41 - Inside the pain cave13:46 - Why she went back ten times16:51 - Bonking, hydration, and what changed21:12 - Finding your why28:04 - Running for something greater33:25 - Strong over fast: the real secret35:59 - The lifting myths men and women believe44:13 - Where a beginner should start47:02 - Sit to stand: the non-negotiable move48:56 - The habit that killed her father51:11 - Why falls are so devastating54:14 - The danger of low-protein advice for older adults59:00 - Stop waiting for Monday01:01:37 - Fueling: protein, sodium, and calories per hour01:13:01 - Why a DNF isn't failure01:18:13 - Unfinished business and the right choiceIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    1 hr and 23 mins
  • Laura Horvath, Chris Hinshaw & James Sprague: What Separates Champions From Everyone Else

    Laura Horvath, Chris Hinshaw & James Sprague: What Separates Champions From Everyone Else
    Jun 18 2026

    What does it actually mean to win at the highest level? In this powerful compilation, I’m with 2024 CrossFit Games champion James Sprague, 2023 CrossFit Games champion Laura Horvath, and legendary endurance coach Chris Hinshaw to unpack the mental game behind elite performance, the vulnerability that follows victory, and why champions are often more fragile in the moments just after they win. What does winning mean to you right now?

    Connect with James Sprague

    Website: https://games.crossfit.com/athlete/900251

    YouTube: https://youtube.com/@spraguerrrr?si=zTrH9d5valcjlq-t

    Instagram: https://www.instagram.com/spraguerrrr/

    Facebook: https://www.facebook.com/spraguerrrr/

    Connect with Laura Horvath

    Website: https://games.crossfit.com/athlete/591912

    YouTube: https://youtube.com/@kaduzs23?si=3j8mXAnf38H7uGvi

    Instagram: https://www.instagram.com/laurahorvaht/?hl=en

    Facebook: https://www.facebook.com/laurhorvath/

    TikTok: https://www.tiktok.com/@laurahorvaht

    X: https://x.com/laurahorvaht

    Connect with Chris Hinshaw

    Website: https://www.aerobiccapacity.com/

    Instagram: https://www.instagram.com/hinshaw363/

    Facebook: https://www.facebook.com/hinshaw363/

    Thank you to our sponsors:

    Bodyhealth - Use the code “LYON20” to get 20% off your first order! https://bit.ly/4r2ImeF

    Our Place - Use code “DRLYON” for 10% of sitewide. https://bit.ly/4r77SiU

    Manukora - save 31% plus $25 worth of free gifts. https://bit.ly/4sglER1

    Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

    YouTube: https://bit.ly/4boCFC3

    Spotify: https://bit.ly/4cWTbLG

    Connect with Dr. Gabrielle Lyon:

    Instagram: https://www.instagram.com/drgabriellelyon/

    TikTok: https://www.tiktok.com/@drgabriellelyon

    X (Twitter): https://x.com/drgabriellelyon

    Facebook: https://www.facebook.com/doctorgabriellelyon

    Timestamps:

    00:00 - Intro of Show

    00:52 - The Rogue Invitational and qualifying

    01:41 - Applying friction in elite training

    02:27 - Why winners are vulnerable

    02:47 - CrossFit and HYROX recovery demands

    03:23 - Active versus passive rest

    04:14 - Why records keep breaking

    05:18 - Training by feel without wearables

    06:16 - Mastering movement before intensity

    07:21 - Reframing pain as growth

    08:25 - How CrossFit events are structured

    09:47 - Building structural integrity

    10:38 - The three bases of the sport

    11:34 - Getting comfortable being uncomfortable

    ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    This episode includes paid sponsorships.
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    13 mins
  • What Your ED Is Really Telling You About Your Heart, Blood Sugar & Hormones - Urology Roundtable

    What Your ED Is Really Telling You About Your Heart, Blood Sugar & Hormones - Urology Roundtable
    Jun 16 2026
    Most men think erectile dysfunction is a bedroom problem and low testosterone is just a fact of getting older. This roundtable makes the case that both are early warning lights for your heart, your metabolism, and your long-term health and that ignoring them can cost you a decade.In this episode, Dr. Gabrielle Lyon sits down with urologists and men's health specialists Dr. Mohit Khera, Dr. Larry Lipshultz, and Dr. Tobias Köhler to discuss:Why a 35-year-old with ED carries a ~15% risk of heart attack or stroke within 7 years, ~3.5x the risk of depression, and ~30% odds of diabetes or prediabetes and why a prescription alone misses all of itWhy "age-related" testosterone decline is largely a misnomer: a healthy man shouldn't drop significantly with age, so falling T usually signals something reversible underneathHow testosterone became the single best blood marker of a man's overall health, and the case for annual screening that almost no man getsWhat the TRAVERSE trial changed when the FDA removed testosterone's cardiovascular warning in 2025, debunking the prostate-cancer and heart-attack fearsThe 2-minute monthly self-exam every man should do to catch testicular cancer early, when it's ~99% curableIf you've been told your symptoms are "just aging" or you love a man who refuses to see a doctor. This conversation shows you how to read the signals your body gives long before a crisis hits.Thank you to our sponsors:Body Health - Use the code LYON20 to get 20% off your first order https://bit.ly/4efgBuMTimeline - Get 20% off your Mitopure order at https://bit.ly/49LSbYzBranch Basics - Save 15% at https://bit.ly/4uuw4x3 with code DRLYONExplore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Larry Lipshultz at:Instagram: https://www.instagram.com/lipshultzmd?igsh=NTc4MTIwNjQ2YQ==Website: https://www.larrylipshultz.com/YouTube: https://www.youtube.com/@DrsAmyandLarryFind Dr. Tobias KohlerInstagram: https://www.instagram.com/tobiaskohlermd?igsh=NTc4MTIwNjQ2YQ==X: https://x.com/sexhealthmd?s=11Find Dr. Mohit KheraInstagram: https://www.instagram.com/drmohitkhera?igsh=NTc4MTIwNjQ2YQ%3D%3DX: https://x.com/DrMohitKheraWebsite: https://drmohitkhera.com/Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction01:30 - What doctors got wrong about testosterone05:05 - The prostate cancer myth, debunked07:12 - The best marker of a man's health11:51 - Is age-related decline actually real?14:15 - How obesity crushes testosterone18:11 - Testosterone and reversing diabetes20:06 - GLP-1 versus testosterone25:20 - What "low testosterone" really means29:05 - Dosing, CAG repeats, and microdosing42:34 - The TRAVERSE trial and FDA reversal47:10 - The prostate saturation point56:49 - Peptides, explained01:03:00 - Why ED is a check engine light01:08:26 - The desert of men's health care01:11:06 - The case for annual screening01:16:45 - Varicoceles and male fertility01:20:03 - How to check for testicular cancer01:26:44 - Final advice for menIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    1 hr and 33 mins
  • How to Stay Calm in a Crisis and Why Detachment Is a Trainable Skill - Jamie Cochran

    How to Stay Calm in a Crisis and Why Detachment Is a Trainable Skill - Jamie Cochran
    Jun 9 2026
    Your ego isn’t the enemy, but if you’re not actively controlling it, it is running your team, your home, and your most important relationships. Jamie Cochran, COO of Echelon Front, has spent 13 years helping leaders fix the root cause most of them never look for.The Women’s Leadership Assembly live event runs January 5–7, 2027 in Palm Springs. A free monthly webinar series runs year-round. More details here: https://events.echelonfront.com/product/assembly-004/?utm_source=google&utm_medium=cpc&utm_campaign=22652941380&utm_content=&utm_term=&utm_source=google&utm_medium=paid&utm_campaign=22652941380&utm_content=&utm_term=&gadid=&gad_source=1&gad_campaignid=22662710098&gclid=CjwKCAjwxITRBhBYEiwA6mZm7VZs1jY-jUq1ugoigo8XEDkYsRsSEpOs2eblax5TQOW-9LT_K-hVhBoC1RkQAvD_BwEThank you to our sponsors:Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGNBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/4uR4NWBUpgrade your kitchen with Our Place today. Visit https://bit.ly/4dSD4Pz and use code DRLYON for 10% off sitewide.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Jamie Cochran at:Website: https://echelonfront.com/YouTube: https://youtube.com/@echelonfront?si=2x5aCudkXTvicfJOInstagram: https://www.instagram.com/jamielynncochran/Facebook: https://www.facebook.com/jamie.cochran.7/LinkedIn: https://www.linkedin.com/in/jamie-lynn-cochran-5ab79013Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 ​Intro of Show01:33 The Spartan Warrior Selection02:25 Why Female Leadership Is Misunderstood06:35 Are Leadership Tools Evolving or Constant?07:12 What Is Extreme Ownership?11:44 Owning It All vs. Doing It All12:34 Female Leadership: Strength vs. Confidence vs. Aggression17:57 Imposter Syndrome: Healthy or Dangerous?23:37 Leadership Skills: Natural or Trainable?31:00 Detachment from Emotion: On Making Better Decisions32:32 Healthy Competition Against Women36:20 Jamie’s Thyroid Cancer Diagnosis and Practicing Detachment48:12 Avoidant Leaders and Default Aggressive Bias for Action51:96 Top 3 Mistakes Leaders Make52:43 The Leadership Capital Framework57:54 The PIOS Framework: Problem, Impact, Ownership, Solution1:00:10 When to End a Professional Relationship1:04:29 The Women’s Leadership Assembly: Origin Story1:07:05 Impact of Social Media on the Confidence of Young Girls1:13:35 Compounding Habits that Improve Leadership over Time1:14:55 Discipline as a Parenting Tool1:22:07 Recognising when your Leadership Capacity is Failing1:24:51 Women’s Assembly in January 2027: Palm SpringsIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    1 hr and 27 mins
  • Penis Health, What Every Man Needs to Know - Dr. Amy Pearlman

    Penis Health, What Every Man Needs to Know - Dr. Amy Pearlman
    Jun 2 2026
    Most men think erectile dysfunction is a bedroom problem. It's actually one of the earliest warning signs of cardiovascular disease, capable of showing up three to five years before a heart attack.In this episode, Dr. Gabrielle Lyon sits down with Dr. Amy Pearlman, a urologist trained in men's sexual health, to discuss:Why ED is a symptom of vascular health, not a standalone disease and how the artery feeding the heart is roughly double the size of the one feeding the penis, so problems show up "down there" firstWhy "normal" testosterone can be meaningless, and the questions to ask before accepting a lab result that didn't flagHow daily erections preserve penile tissue the way water keeps a sponge supple and why disuse can cost noticeable size over just a few monthsThat cardiovascular exercise can rival ED medication for improving erectile function, making your heart health the real fixHow to track erectile fitness before there's a problem, instead of waiting until something breaksBy the end, you'll understand the single signal your body uses to flag heart and metabolic risk early and the simple, mostly drug-free steps that protect both your cardiovascular health and your sexual function for life.Thank you to our sponsors:Manukora - Go to https://bit.ly/3RCMrKx to save 31% plus $25 worth of free gifts.Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGNBon Charge - Save 15% at https://bit.ly/433Xi2B with code DRLYONExplore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Listen to "Pearls of Wisdom" on all your favorite platforms!Spotify: https://open.spotify.com/show/4uOhWn5DeVXO7D2ppa0RoVApple Podcasts: https://podcasts.apple.com/us/podcast/pearls-of-wisdom/id1617916659Find Dr. Amy Pearlman at:Website: https://www.primeinstitute.us/YouTube: https://youtube.com/@docamyurology?si=oJ2LZ_sxMPYTaK41Instagram: https://www.instagram.com/amypearlmanmd/X: https://x.com/AmyPearlman1LinkedIn: https://www.linkedin.com/in/amy-pearlman-54a2b0208Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonTimestamps00:00 - Introduction01:25 - Erections predict cardiac events01:41 - The pen and artery analogy03:40 - No health milestones for men07:52 - Normal structure and function11:45 - The five S's of men's health21:24 - Why "normal" testosterone misleads25:00 - Testosterone and fertility risk31:05 - Steroids versus FDA-approved agents41:13 - The untreated 25-year-old43:56 - Sperm health and home testing52:02 - Peyronie's disease and injury1:01:34 - Protein, nutrition, supplements1:05:09 - Daily Cialis as a pre-workout1:13:32 - The sponge analogy1:15:31 - Erectile fitness tracking1:23:05 - The penis pump, used right1:27:24 - Restoring lost size1:35:00 - Traction and girth enhancement1:46:00 - Women's anatomy and pleasureIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    1 hr and 53 mins
  • Your Doctor Is Watching the Wrong Number. LDL, ApoB & Heart Risk Explained. - Dr. Kevin Maki

    Your Doctor Is Watching the Wrong Number. LDL, ApoB & Heart Risk Explained. - Dr. Kevin Maki
    May 26 2026
    Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    1 hr and 25 mins
  • The Cancer Doctors Keep Missing in Young Adults - Dr. Michelle Pearlman

    The Cancer Doctors Keep Missing in Young Adults - Dr. Michelle Pearlman
    May 19 2026
    Colorectal cancer is now the leading cancer killer in adults under 50, and patients in their 20s are presenting with metastatic disease that has nothing to do with family history. Most physicians are still telling young patients with rectal bleeding that it's probably just hemorrhoids and that's costing lives.In this episode, Dr. Gabrielle Lyon sits down with Dr. Michelle Pearlman, a board-certified gastroenterologist and founder of a Miami-based gastro-metabolic clinic, to discuss:The specific warning signs every adult under 50 should never ignore, regardless of age including rectal bleeding, unintentional weight loss, and persistent abdominal painWhy GLP-1 medications like Ozempic and Zepbound are being miscategorized as weight loss drugs when they're actually metabolic reprogrammers with applications in fatty liver, sleep apnea, and inflammationThe protein, fiber, and resistance training protocol Dr. Pearlman uses to protect muscle mass in patients on GLP-1 therapyHow hormone replacement therapy combined with GLP-1s is changing body composition outcomes for perimenopausal women and why current guidelines are still 20 years behind the dataDr. Pearlman's personal osteoporosis diagnosis at 39, despite being a lifelong bodybuilder, and what it revealed about the diagnostic gaps in standard medicineThis conversation gives you the framework to recognize the warning signs most physicians are still missing, and the foundational habits; nutrition, resistance training, and hormone optimization that protect your gut, bones, and muscle through midlife and beyond.Thank you to our sponsors: Cozy Earth - Go to https://bit.ly/4teXQhz for up to 20% off!Timeline - Get 20% off your Mitopure order at https://bit.ly/4eLBWhBLucy - Get 20% off your next order with code DRLYON at https://bit.ly/42HiUlc, or find yours in store at https://bit.ly/3RfGnYaAmp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Michelle Pearlman at:Instagram: https://www.instagram.com/michellepearlmanmd/Website: https://www.primeinstitute.us/Connect with Dr. Gabrielle LyonInstagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction: Colorectal cancer under 5001:15 - The gastro-metabolic approach explained03:30 - Why nutrition isn't taught in GI fellowship05:45 - When the colonoscopy is normal but patients suffer07:00 - Weight, reflux, and visceral fat09:15 - PPIs, bone density, and long-term risk11:30 - Three things to never do for gut health14:00 - Ultra-processed food and early-onset cancer16:45 - Rectal bleeding, warning signs, and age19:00 - Screening guidelines and the obesity gap22:30 - GLP-1 medications: history and mechanism27:15 - Hunger, cravings, and food noise30:00 - The stigma around metabolic medications33:45 - Side effects: nausea, reflux, constipation38:30 - Compounded formulations and pharmacy safety42:00 - Hair loss, protein, and supplementation45:15 - Pill versus injection delivery systems49:30 - Fiber, the microbiome, and short-chain fatty acids54:00 - GLP-1s plus hormone replacement therapy58:45 - Testosterone, Kyzatrex, and women's bone health1:03:00 - Pearlman's osteoporosis diagnosis at 391:09:30 - The diagnostic gap in standard medicine1:14:00 - Building Bite MD and the future of nutrition techDisclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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    2 hrs and 3 mins