When Dr. Lara Jehi began treating epilepsy patients in the 2000s, critical surgical decisions were driven more by clinician intuition and expertise than data. Today, she is a leader of IBM and Cleveland Clinic’s Discovery Accelerator, using advanced AI and quantum computing to transform how researchers analyze data, simulate molecules, accelerate drug discovery, and develop more precise treatments. Malcolm Gladwell talks with Dr. Jehi about how quantum computing is changing biomedical research, and what these breakthroughs could mean for the future of healthcare and life sciences.

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Will AI bots replace humans in the workforce? Could one replace Evan… right now? That’s what we tackle on this week’s Shell Game, in which Evan sees just how much of his job his voice agent can handle on his behalf. Shell Game is made by humans. More specifically, it's made by three humans: Evan Ratliff (host and writer), Sophie Bridges (producer), and Samantha Henig (executive producer). Visit shellgame.co to find out more and support the show.

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Is building data centers in space actually feasible? It may be, thanks to Ariel Ekblaw. The scientist, VC investor and co-founder and CEO of Aurelia Institute has devoted her life to democratizing space and ensuring that humans will one day be a spacefaring species. Ariel sits down with Oz to discuss self-assembling space architecture, how science-fiction influences her inventions, and why she doesn’t think billionaires investing in space is a bad thing.

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How close are we to human extinction because of AI? Leading AI expert Professor Stuart Russell believes we’re much too close for comfort and has been raising the alarm for a few years. Ironically, Stuart himself wrote the book that laid the foundation for AI research back in the 1990s. And he was the only AI expert Elon Musk’s team called upon during their trial with OpenAI.

Stuart joins Oz to discuss what changed his mind about pursuing AI superintelligence and makes the argument that human extinction is being treated as an external liability in favor of shareholders.

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Evan looks into the depths of his AI-powered voice agent by sending it on a new mission: going to therapy. Shell Game is made by humans. More specifically, it's made by three humans: Evan Ratliff (host and writer), Sophie Bridges (producer), and Samantha Henig (executive producer). Visit shellgame.co to find out more and support the show.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.shellgame.co/subscribe

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How much of what you see online is actually real? This week, Reed Albergotti (Semafor) breaks down Anthropic's latest clash with the Trump Administration. Is Anthropic’s own messaging to blame? Then, Nitasha Tiku (The Washington Post) talked to students that walked out on Google CEO Sundar Pichai's commencement speech at Stanford. Their protest was about much more than AI. Finally, Taylor Lorenz (User Mag) exposes the fake "caught cheating" videos flooding social media, which are secretly ads for vibe-coded apps promising to catch the unfaithful.

Additional Reading:

• US Limits Use of Anthropic AI Models Fable 5 and Mythos | Semafor
• The White House Said Anthropic’s Powerful AI was ‘jailbroken.’ Here’s What That Means | The Washington Post
• Sundar Pichai faces boos, walkout at Stanford graduation ceremony over Google's Israel, ICE ties | TechCrunch
• The Secret Stanford Off-Campus Class for Tech’s Next Titans - The Story | TechStuff

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Is AI happening to you — or for you? Pew Research found that 50% of Americans are more concerned than excited about artificial intelligence. Michele Jawando and John Palfrey think that's a signal that more people need to get involved.

Oz sits down with Michele, CEO of the Omidyar Network, and John, president of the MacArthur Foundation, to unpack Humanity AI: a coalition of ten major philanthropies pooling $500 million to ensure the future of AI is shaped by — and for — everyone. Along the way, they get into why Michele believes "AI is not destiny, it is design," how Humanity AI grantees are using the technology to serve the public good and what success will look like for the collaborative effort.

Additional Reading:

• What the data says about Americans’ views of artificial intelligence | Pew Research Center
• Humanity AI

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Evan takes his experiment in a new direction by having his AI-powered voice agent converse with … another of his AI-powered voice agents. What can these surreal and hilarious conversations between two AI incarnations of Evan Ratliff tell us about identity, authenticity, and the best and worst of human interaction? Enter this digital hall of mirrors to find out.Shell Game is made by humans. More specifically, it's made by three humans: Evan Ratliff (host and writer), Sophie Bridges (producer), and Samantha Henig (executive producer). Visit shellgame.co to find out more and support the show.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.shellgame.co/subscribe

See omnystudio.com/listener for privacy information.

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