We close out our Mad Science series the only way we know how: with a very serious, deeply prestigious and completely unofficial Mad Science Film Awards.

After 58 films and more than a century of sci-fi cinema, we look back at the scientists, monsters, labs, experiments and terrible decisions that defined the season.

From Frankenstein, Dr. Jekyll and Mr. Hyde and The Invisible Man to The Fly, Re-Animator, Jurassic Park, Get Out and Poor Things, we trace how mad science evolved from gothic cautionary tales to atomic-age anxiety, body horror, corporate genetics, surveillance, consent and control.

Categories include Best Mad Scientist, Biggest Ego in a Lab Coat, Most Unethical Experiment, Best Creation, Best Lab, Hidden Gem and the big one: Best Mad Science Movie.

Plus we unveil what we will be covering the next series of Jounrey Through Sci-fi!

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This week on Journey Through Sci-Fi, we head into the Star Trek universe to explore one of its most enduring mad science taboos: genetic engineering. From Space Seed and the rise of Khan to Enterprise's Augments arc and Deep Space Nine's shocking Bashir reveal, we trace how Star Trek keeps returning to the dangers of trying to "improve" humanity.

Along the way, we get into the Eugenics Wars, creator-creation relationships, scientific hubris, and why a utopian future still casts a long shadow over forbidden science.

Plus: Brent Spiner being superbly awful, Bashir's identity crisis, and why this theme runs through Star Trek for more than 200 years of in-universe history.

Episodes discussed:
Star Trek: The Original Series — "Space Seed" (S1E22)
Star Trek: Enterprise — "Borderland" (S4E04), "Cold Station 12" (S4E05), "The Augments" (S4E06)
Star Trek: Deep Space Nine — "Doctor Bashir, I Presume?" (S5E16)

Also referenced:
Star Trek — "What Are Little Girls Made Of?"
Star Trek: The Next Generation — "The Schizoid Man"
Star Trek: Voyager — "Tuvix"

What happens when one of sci-fi's oldest stories is reimagined for a modern audience?

In this episode of Journey Through Sci-Fi, we return to the origin of mad science — Mary Shelley's Frankenstein — through two new adaptations: Frankenstein (2025), directed by Guillermo del Toro, and The Bride! (2026), directed by Maggie Gyllenhaal.

This isn't just another adaptation.

It's a full-circle moment for the genre.

From the obsessive creator who dares to make life… to the creation who refuses to belong to him, these films show how the Frankenstein myth has evolved over 200 years of science fiction.

In this episode we explore:

• Why Frankenstein is still the blueprint for every mad scientist story
• How these new versions reinterpret the act of creating life
• What they keep — and what they completely reinvent — from the original myth
• Why The Bride! flips the perspective from creator to creation
• What this tells us about where sci-fi — and mad science — is heading next

From gothic horror roots to modern sci-fi storytelling, this is the evolution of one of the genre's defining ideas.

And a fitting end point for our Mad Science series.

Because sometimes the most important sci-fi story isn't about the future…

…it's the one we've been retelling all along.

In this episode of Journey Through Sci-Fi, we dive into the terrifying idea of mad science controlling the human mind through two modern sci-fi horror films: Get Out (2017) and Possessor (2020).

Jordan Peele's Get Out hides a chilling science-fiction twist beneath its social horror story, revealing a sinister procedure designed to take over another person's body and consciousness. Meanwhile, Brandon Cronenberg's brutal cyberpunk thriller Possessor imagines a world where corporations use technology to possess people's minds and carry out assassinations.

We explore how both films tap into classic sci-fi ideas about identity, consciousness and control, while pushing the mad scientist trope into disturbing new territory.

Expect discussion on:

• The terrifying sci-fi twist behind Get Out

• The mind-transfer technology in Possessor

• How horror and science fiction overlap in the mad science genre

• Why stories about losing control of your own body remain so powerful in sci-fi

🎧 Listen now for our deep dive into mind control, body swapping and the dark side of scientific ambition.

Two kidnappings and two grotesque transformations.

Listener discretion advised...

This week on Journey Through Sci-Fi, we head into the grisliest corner of our Mad Science season as we explore The Human Centipede (2009) and Tusk (2014).

From Tom Six's clinically cold, torture-era nightmare to Kevin Smith's surreal walrus transformation, both films twist the mad scientist archetype into something deeply insular... not driven by progress, but by obsession.

In The Human Centipede, Dr Heiter's experiment is cold, clinical and cruel - a Frankenstein figure filtered through torture cinema.

In Tusk, Howard Howe isn't chasing science at all - he's chasing memory, trauma and a warped sense of redemption.

We unpack:

• The torture-porn moment of the 2000s and its legacy
• The "100% medically accurate" myth
• Mad science as private fetish rather than public breakthrough
• God complexes, conditioning and forced transformation
• Comedy vs horror - why Tusk makes you laugh and recoil
• And why these scientists don't want to change the world… just their victims

From surgical body horror to psychological conditioning, this is mad science stripped of romance and left with nothing but obsession.

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Two Marvel origin stories. Two very different mad scientists. Only one built a cinematic empire.

This week, we revisit Hulk (2003) and Iron Man (2008) to explore the science behind the superheroes and why one experiment failed while the other changed blockbuster cinema.

Ang Lee's Hulk is a tragic tale of inherited trauma, gamma radiation and fractured identity, a full-blown mad science horror hiding inside a superhero movie.

Iron Man flips the formula: no monster, no accident, just a billionaire engineer weaponising his own genius and building the future in a cave.

From Frankenstein echoes to high-tech spectacle, this is the moment Marvel transformed mad science into the foundation of the MCU.

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This week on Journey Through Sci-Fi, we're heading into murkier, creepier territory as we pair Mimic and Splice - two films that take mad science out of the lab and straight into body-horror nightmare fuel.

Directed by Guillermo del Toro and Vincenzo Natali, they arrive from very different moments in sci-fi cinema. Mimic comes out of the late-90s creature-feature era, mixing practical effects with early CGI and big studio ambition. Splice, released over a decade later, taps into anxieties around gene splicing, biotech, and scientists who really should know better.

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We look back at the biggest sci-fi moments of 2025 — franchise returns, standout TV, Marvel's slump, DC's revival, and the auteur films that kept the genre interesting. From Superman and 28 Years Later to Severance and Alien: Earth, we break down what landed, what didn't, and what comes next for JTSF.

• Visit our website https://www.journeythroughscifi.com/
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