The Story of DanGer Shock and the Future of the Microaxial Flow Pump with Dr. Jacob Møller cover art

The Story of DanGer Shock and the Future of the Microaxial Flow Pump with Dr. Jacob Møller

The Story of DanGer Shock and the Future of the Microaxial Flow Pump with Dr. Jacob Møller

Listen for free

View show details
After more than two decades without a major positive randomized trial in cardiogenic shock, is the evidence finally catching up to the technology? In this episode of SoCCC Pre-Rounds, Dr. Simon Parlow sits down with Dr. Jacob Møller, critical care cardiologist and professor at the University Hospital Copenhagen, to unpack microaxial flow pumps and the landmark DanGer Shock trial. Dr. Møller shares how persistence, collaboration, and a bit of luck helped drive a breakthrough in a field that has long needed one.They explore how these devices work at the bedside, from unloading the left ventricle to reducing myocardial oxygen demand, and what that means in real-world care. The conversation also dives into the challenges of running a high-stakes trial in critically ill patients, along with practical insights on patient selection, complications, lactate trends, and weaning strategies. It’s a sharp look at one of the most important recent advances in cardiogenic shock and where clinicians are still forced to operate without clear evidence.Microaxial flow pumps unload the left ventricle: By reducing preload and stroke work, they may lower myocardial oxygen demand and support recovery in shock states.The DanGer Shock trial changes the landscape: It’s the first major positive randomized trial in cardiogenic shock in over 20 years, targeting a highly selected STEMI population.Patient selection is everything: Only a small fraction of shock patients were eligible, highlighting how precise clinicians must be when applying this therapy.Weaning starts earlier than we thought: The most critical window may be the first 12–24 hours, with earlier reassessment for device removal.Evidence is still evolving: Outside of trial populations, clinicians must rely on judgment when considering use in non-STEMI or non-ischemic shock.[00:00] Introduction to SoCCC Pre-Rounds[00:57] Live from ACVC 2026: introducing Dr. Jacob Møller[01:15] What are micro axial flow pumps and how do they work?[03:52] The origin and evolution of the DanGer Shock trial[06:39] Trial results and why they were unexpected[07:48] Expanding beyond STEMI: real-world patient selection[09:44] Monitoring patients: lactate and hemodynamic trends[10:20] Early management challenges and complications[11:36] Rethinking weaning strategies[12:05] Role of guideline-directed therapy during support[12:57] Lessons from running a major clinical trial[14:03] Building a research culture in critical care[07:51] "After seeing the results of DanGer, we have probably become a little bit more liberal in using the device in other forms of ischemic, like non-STEMI shock." — Dr. Jacob Møller[09:46] "We look at trajectories, and we look a lot at lactate. Lactate has to go down in these patients; otherwise, something is wrong." — Dr. Jacob Møller[10:33] "You look at the trajectory, so if it goes from 1.5 and starts going down, then you know there's something wrong." — Dr. Jacob Møller[13:57] "I'm working in a very small cardiac ICU; we only have seven beds, but we randomized more than 100 patients with out-of-hospital cardiac arrest every year." — Dr. Jacob MøllerBecome a member of the Community: https://www.soccc.org/subscribeDr. Jacob Møllerhttps://www.linkedin.com/in/jacob-eifer-m%C3%B8ller-1b2398300/?locale=enhttps://www.rigshospitalet.dk/Dr. Simon Parlowhttps://www.ottawaheart.ca/profile/parlow-simonSupported By:This episode is made possible by unrestricted support from Zoll LifeVest — thanks for keeping high-impact education free for our community.DisclaimerThis podcast is not medical advice, just candid, practical discussions about what your hosts do every day in the CICU. Always consult your supervising team and current guidelines before applying any interventions.
adbl_web_anon_alc_button_suppression_t1
No reviews yet