Episodes

  • Sean Khozin, MD: From Revolution to Precision Oncology

    Sean Khozin, MD: From Revolution to Precision Oncology
    May 13 2026
    Sean Khozin has lived through revolution, rebuilt from scratch, and gone on to help reshape modern oncology. In this episode of Get Real, Sean shares his journey from fleeing Iran as a child to leading at the highest levels of cancer research, regulation, and innovation at the NCI, FDA, Johnson & Johnson, and now as CEO of the CEO Roundtable on Cancer. We explore why cancer is always personal, how AI can restore the doctor‑patient relationship, and why data must become liquid to unlock precision medicine. This is a wide‑ranging chat about science, freedom, music, and why the future of healthcare only works if it starts with the patient.
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    48 mins
  • Dr. Robert Califf on the Future of Public Health

    Dr. Robert Califf on the Future of Public Health
    May 6 2026
    Former FDA Commissioner, practicing cardiologist, and adjunct professor at Duke University, Dr. Robert Califf joins the conversation to unpack the complex world of public health, drug regulation, and medical innovation. He offers a clear-eyed perspective on how the U.S. Food and Drug Administration makes decisions that impact millions of lives. Dr. Califf explores the ongoing effort to build public trust in science and emphasizes why that trust is essential to better health outcomes. He also shares insight into the future of healthcare, from data-driven medicine to the role of prevention in improving outcomes across populations. This episode is a thoughtful look at the systems that shape modern medicine and what it will take to make them work better for everyone.
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    38 mins
  • Bravery Is A Practice with Jill Schulman

    Bravery Is A Practice with Jill Schulman
    Apr 29 2026
    Bravery expert, Jill Schulman, author of The Bravery Effect, reframes bravery as a trainable skill rather than an innate trait. She explains how “bravery reps” build confidence and self-trust by acting despite fear, and why fear is often a social signal pointing toward growth rather than real danger. Drawing on science, psychology, and her own experience, Jill outlines a three-part framework for courage: mindset, behavior, and environment. In an era where AI democratizes knowledge, she argues that bravery and human connection are the new differentiators for success. The conversation explores how avoiding discomfort fuels anxiety, how leaning into fear builds resilience, and why cultivating a “brave tribe” of mentors accelerates growth. From workplace candor and innovation to personal confidence and leadership, this episode shows how practicing courage transforms performance, relationships, and well-being.
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    31 mins
  • From PCR to Portfolio: Christine Aylward is Funding Life Sciences

    From PCR to Portfolio: Christine Aylward is Funding Life Sciences
    Apr 22 2026
    Christine Aylward is the founder and managing partner of Magnetic Ventures, a VC built on a thesis: the future of life sciences will be technology-driven. Her bet, placed in 2018, is paying off. Her path to venture capital is unique. She started at Roche, working on PCR, arguably the most revolutionary technology at the intersection of tech and life sciences in the last century. Then she co-founded a media company with Natalie Portman. Then she launched Magnetic, raising money for companies using machine learning to transform drug discovery, clinical trials, and more. Jim and Christine get into what it really takes to spot transformative science before it's obvious, why machine learning matters more than the word AI, and why the translation from technology to product is so hard.
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    41 mins
  • Barry Sanders Takes on Heart Disease with Amgen

    Barry Sanders Takes on Heart Disease with Amgen
    Apr 15 2026
    Barry Sanders knows what it means to perform at the highest level, but today his focus is on something far bigger than football. In this episode, the legendary NFL running back opens up about his partnership with Amgen and his mission to raise awareness around heart disease, one of the leading causes of death worldwide. His heart attack on Father’s Day in 2024 was a wake up call. Today he is working with Amgen to explain why prevention, early detection, and education are critical, especially in communities that are often overlooked. He also breaks down the realities of cardiovascular risk, the role of lifestyle and genetics, and what people can do right now to better protect their heart health. This conversation goes beyond the stats and science. It is about using influence for impact.
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    18 mins
  • Reclaim Your Nature with Jamie Wheal

    Reclaim Your Nature with Jamie Wheal
    Apr 8 2026
    Peak performance expert Jamie Wheal explores why modern wellness culture may be overcomplicating what it means to feel whole, resilient, and alive. As the founder of Flow Genome Project and co-author of Stealing Fire and Recapture the Rapture, Wheal blends psychology, neuroscience, and ancient practices to explain how humans access peak states, meaning, and connection. He challenges the billion-dollar biohacking industry, arguing that many tools we seek externally already exist within our physiology and rituals practiced for millennia. From breath rhythms embedded in prayer to the transformative power of time in nature, Wheal explains why getting outside, stepping away from screens, and confronting mortality can reconnect us to ourselves. The conversation explores flow states, psychedelics and mental health, meaning in the age of AI, and why no algorithm can tell you what your soul actually needs. In a hyperconnected world, Wheal makes a compelling case for reclaiming direct experience, embodied practice, and the courage to live fully aware of life’s
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    37 mins
  • Paul Kidwell on Grief, Caregiving & Moving Forward

    Paul Kidwell on Grief, Caregiving & Moving Forward
    Apr 1 2026
    Jim sits down with his friend Paul Kidwell, caregiver, advocate, and fellow widower, for a conversation about what it means to lose someone you love. In 2025, both Jim and Paul lost their wives. Jim to cancer. Paul to Parkinson's. They talk about the guilt, the grief, the impossible math of caregiving, and the moment Paul realized this had to become something bigger than just his and his late wife's story. This is a conversation about endurance. It's about the inevitable role we all take on: caregiver. It's also about what comes next, when the caregiving ends, and you're left figuring out who the new you has to become.
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    37 mins
  • Feel Good with Peloton Instructor Aditi Shah

    Feel Good with Peloton Instructor Aditi Shah
    Mar 25 2026
    Aditi Shah is a yoga and meditation teacher, speaker, and wellness advocate, best known as one of Peloton's most beloved instructors. She was recruited in 2018 to help launch their yoga and meditation platform from the ground up. She studied math at Rutgers, moved to Mumbai, and found her calling on a yoga mat. That's a career pivot worth talking about. Jim sits down with Aditi to talk about how to stay well when your phone never stops buzzing. There's a pressure to perform wellness on social media, and it's costing us our health. Aditi is willing to address this head-on. She's brave. She's candid. She's the real deal. Tune in.
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    42 mins