What does long-term GLP-1 use actually look like in real life?

In this episode, Ana sits down with clinical pharmacist Kimmi Le of Solara Labs/Barimelts to talk about the bigger picture of staying on GLP-1 medications over time. They unpack why weight loss alone is not the same thing as better health, what labs and biomarkers matter most, and how to think about muscle, nutrient status, digestion, inflammation, and long-term maintenance. Kimmi shares a practical perspective on microdosing, why some patients may do better staying on a lower long-term dose, and how to avoid the cycle of losing and regaining weight. They also talk about nutrient absorption, supplement quality, bariatric surgery considerations, and what may be coming next in the GLP-1 space.

In this episode, you’ll learn:

• Why “the scale going down” doesn’t always mean health is improving
• The role of exercise and muscle preservation on GLP-1s
• How slowed digestion can affect nutrient absorption
• What bariatric patients should keep in mind when using GLP-1 medications
• Why form and quality matter when choosing supplements
• How clinicians are thinking about long-term use, lower dosing, and maintenance

About Kimmi Le: Kimmi Le is a clinical pharmacist with additional training in nutrition, herbalism, and culinary medicine through Tulane Medical School’s teaching kitchen. She works in the supplement space with Solara Labs/Barimelts, with a focus on practical support for women using GLP-1 medications and bariatric patients.

Episode Sponsors:

Barimelts: https://www.barimelts.com/

Brello: A GLP-1 telehealth platform connecting you with licensed providers. Visit http://brello.com to learn more.

Timeline Mitopure: Go to timeline.com/glp1hub for up to 20% off.

Want to Learn More about GLP-1 Hub?

Join the Steady State newsletter and get a FREE 7-day meal plan + weekly support and strategy to optimize your journey:

http://join.glp-1hub.com

Join the membership:

https://glp-1hub.com/membership

Visit our GLP-1 Hub store:

https://shop.glp-1hub.com

Want to connect more with GLP-1 Hub?

Instagram: https://www.instagram.com/glp1hub

Tiktok: https://www.tiktok.com/@glp1hub

YouTube: https://www.youtube.com/@glp-1hub

*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.

*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

Jess Perreca joins Ana Reisdorf to share his powerful personal story of obesity, massive weight loss, regain, bariatric surgery, and what finally feels different in this season of his life with GLP-1 support. He opens up about growing up with obesity, reaching nearly 600 pounds, losing more than 200 pounds twice, and the emotional patterns that kept pulling him backward. Jess also explains why one of the biggest changes hasn’t just been the weight loss itself, but the relief from pain, inflammation, and swelling that has made everyday life feel more manageable. This is an honest conversation about food noise, emotional eating, shame, persistence, and what it looks like to keep going even after setbacks.

About Our Guest

Jess Perreca Jr. is the creator of Time4Change365 and Everyday Ascend, where he shares an honest look at weight loss, mindset, and what sustainable change really takes. After reaching a high of 588 pounds, Jess lost well over 200 pounds, experienced regain, and recommitted to his health with structure, accountability, and transparency. His journey has included bariatric surgery, GLP-1 medication, and the ongoing mental battle with food noise, shame, and consistency that so many people living with obesity understand firsthand. A husband, father of two, and full-time IT professional, Jess now uses his platforms to encourage others to keep moving forward and become 1% better each day.

Guest Links

Instagram: @time4change365

Instagram: @everydayascendco

Website: everydayascend.com

Want to Learn More about GLP-1 Hub?

Join the Steady State newsletter and get a FREE 7-day meal plan + weekly support and strategy to optimize your journey:

http://join.glp-1hub.com

Join the membership:

https://glp-1hub.com/membership

Visit our GLP-1 Hub store:

https://shop.glp-1hub.com

Want to connect more with GLP-1 Hub?

Instagram: https://www.instagram.com/glp1hub

Tiktok: https://www.tiktok.com/@glp1hub

YouTube: https://www.youtube.com/@glp-1hub

*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.

*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

If you're on a GLP-1 and trying to eat well when your appetite is low, this episode is full of practical, realistic advice. Ana sits down with Cassandra Lepore, known online as @dietitianCass, to break down what smarter snacking actually looks like on a GLP-1. They also dig into what Cassandra is seeing inside the food industry as brands adapt products and messaging for GLP-1 users.

Ana also closes the episode by answering a listener question about GLP-1-related hair loss, including what may cause it, what emerging research is suggesting, and what steps may help right now.

About Our Guest:

Cassandra Lepore is a dietitian and social media nutrition educator known online as @dietitianCass. She works full-time behind the scenes with CPG food and beverage brands, including work focused on how products can better support people using GLP-1 medications. Her work centers on translating evidence-based nutrition into practical, easy-to-understand advice.

Connect with Cassandra Lepore

Instagram: @dietitianCass
TikTok: @dietitianCass
LinkedIn: Cassandra Lepore

Resources mentioned

GLP-1 Hair Loss Cheat Sheet: https://join.glp-1hub.com/hairloss
GLP-1 Hub hair loss YouTube Links:

Fixing Hair Loss on a GLP-1: https://youtu.be/06M5ZU9j-Ww

Hair Loss New Study Update: https://youtu.be/OjFQn6gDreY

Episode Sponsors:

Harvest Snaps — 5g protein and 4g fiber per serving. Use code SNAP15 at HarvestSnaps.com for 15% off through June 30.

Barimelts — Use code GLP1HUB at Barimelts.com for 25% off.

Timeline Mitopure — Go to timeline.com/glp1hub for up to 20% off.

Want to Learn More about GLP-1 Hub?

Join the Steady State newsletter and get a FREE 7-day meal plan + weekly support and strategy to optimize your journey:

http://join.glp-1hub.com

Join the membership:

https://glp-1hub.com/membership

Visit our GLP-1 Hub store:

https://shop.glp-1hub.com

Want to connect more with GLP-1 Hub?

Instagram: https://www.instagram.com/glp1hub

Tiktok: https://www.tiktok.com/@glp1hub

YouTube: https://www.youtube.com/@glp-1hub

*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.

*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.