125: Sleep Chart of Biological Ageing Clocks Across Systems
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125: Sleep Chart of Biological Ageing Clocks Across Systems
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This episode does a deep dive into a 2026 study by the MULTI Consortium that identifies a systemic, U-shaped relationship between sleep duration and biological ageing across the human body. By analyzing data from the UK Biobank, researchers utilized 23 biological ageing clocks derived from MRI imaging, plasma proteomics, and metabolomics to show that both insufficient and excessive sleep accelerate ageing in nine organ systems.
O’Toole CK, Song Z, Anagnostakis F, Yang Z, Tian YE, Duggan MR, et al; MULTI Consortium. Sleep chart of biological ageing clocks in middle and late life. Nature. Published online May 13, 2026. doi:10.1038/s41586-026-10524-5
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