Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the primary users of software instead of humans?

The conversation explores the rise of "headless" software, why APIs and agentic workflows are reshaping enterprise applications, and whether traditional SaaS products are becoming systems of record rather than systems of engagement. They discuss Salesforce's Headless 360 announcement, MCP, enterprise software architecture, and why AI may fundamentally change how businesses interact with their data.

Along the way, they examine what actually makes enterprise software sticky, why replacing systems like SAP and Salesforce is harder than it appears, and where startups have the greatest opportunity as AI reshapes the software stack.

Resources:

Follow Seema Amble on X: https://x.com/seema_amble

Follow Steven Sinofsky on X: https://x.com/stevesi

Follow Elena Burger on X: https://x.com/VirtualElena

Is Software Losing Its Head?
https://a16z.com/is-software-losing-its-head/

The Death of Software? Nah.
https://a16z.com/death-of-software-nah/

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